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Found 102 with Last Name = 'brien' and Initial = 'jf'
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207198(1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hy...)
Affinity DataIC50:  60nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207205(1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanone h...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207201(4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol h...)
Affinity DataIC50:  140nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  300nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31769(Terconazole | cid_5404)
Affinity DataIC50:  410nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183074(4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol ...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31653(CHEMBL421109 | imidazole-dioxolane, 5)
Affinity DataIC50:  520nMAssay Description:In vitro inhibitory concentration against heme oxygenase 1 from rat spleenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM84847(1-azolyl-4-phenyl-2-butanone, 49a | CHEMBL558183)
Affinity DataIC50:  700nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183063((2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazo...)
Affinity DataIC50:  800nMAssay Description:Inhibition of Sprague-Dawley rat spleen HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50190798(3-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31770(Exelderm | Sulconazole Nitrate | cid_65495 | sulco...)
Affinity DataIC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207200(4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanol ...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Homo sapiens (Human))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183063((2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazo...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human spleen HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31655(CHEMBL179494 | imidazole-dioxolane, 7)
Affinity DataIC50:  1.60E+3nMAssay Description:In vitro inhibitory concentration against heme oxygenase 1 from rat spleenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207197(4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanone ...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207205(1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanone h...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of Sprague-Dawley rat brain microsome HO2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207198(1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hy...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of Sprague-Dawley rat brain microsome HO2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207199(1-((2-(2-(4-bromophenyl)ethyl)-1,3-dioxolan-2-yl)m...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207206(4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanone...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Sprague-Dawley rat brain microsome HO2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31654(CHEMBL368045 | imidazole-dioxolane, 6)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibitory concentration against heme oxygenase 1 from rat spleenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207201(4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol h...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of Sprague-Dawley rat brain microsome HO2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183058((2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazo...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207206(4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanone...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183063((2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazo...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of rat liver CYP2E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207207(1-((2-(2-(4-iodophenyl)ethyl)-1,3-dioxolan-2-yl)me...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207203(1-((2-(2-(4-fluorophenyl)ethyl)-1,3-dioxolan-2-yl)...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183062(1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen HO1More data for this Ligand-Target Pair
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183074(4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol ...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Sprague-Dawley rat brain microsome HO2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50161588(3-{(2S,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibitory concentration against heme oxygenase 1 from rat spleenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM84804(1-azolyl-4-phenyl-2-butanone, 6a | CHEMBL536514)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183062(1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183068(1-((2-(4-chlorophenethyl)-1,3-dithiolan-2-yl)methy...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183045(4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31769(Terconazole | cid_5404)
Affinity DataIC50:  5.00E+3nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183062(1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of rat liver CYP2E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31653(CHEMBL421109 | imidazole-dioxolane, 5)
Affinity DataIC50:  5.00E+3nMAssay Description:In vitro inhibitory concentration against heme oxygenase 2 from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50161590(2-{(2S,4S)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataIC50:  5.00E+3nMAssay Description:In vitro inhibitory concentration against heme oxygenase 1 from rat spleenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50044424(4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31771(Isoconazole | cid_3760)
Affinity DataIC50:  5.60E+3nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31772(1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl...)
Affinity DataIC50:  5.80E+3nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50044424(4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Affinity DataIC50:  6.00E+3nMAssay Description:In vitro inhibitory concentration against heme oxygenase 1 from rat spleenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183058((2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazo...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of rat liver CYP2E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50044424(4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM84855(1-azolyl-4-phenyl-2-butanone, 57a | CHEMBL536516)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsome HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  7.00E+3nMpH: 7.4 T: 2°CAssay Description:HO activity in rat spleen (HO-1) and brain (HO-2) microsomal fractions was determined by the quantitation of CO formed from the degradation of methem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50207197(4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanone ...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of Sprague-Dawley rat brain microsome HO2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM84804(1-azolyl-4-phenyl-2-butanone, 6a | CHEMBL536514)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of Sprague-Dawley rat brain microsome HO2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183064((2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazo...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Sprague-Dawley rat spleen HO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50183068(1-((2-(4-chlorophenethyl)-1,3-dithiolan-2-yl)methy...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of rat liver CYP2E1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme oxygenase 2(Rattus norvegicus (rat))
Queen'S University

Curated by ChEMBL
LigandPNGBDBM50161586(4-{(2S,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataIC50:  1.50E+4nMAssay Description:In vitro inhibitory concentration against heme oxygenase 2 from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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