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Target
Enoyl-acyl-carrier protein reductase
Ligand
BDBM50211911
Substrate
n/a
Meas. Tech.
ChEMBL_436468 (CHEMBL904777)
IC50
50000±n/a nM
Citation
 Kumar, G; Parasuraman, P; Sharma, SK; Banerjee, T; Karmodiya, K; Surolia, N; Surolia, A Discovery of a rhodanine class of compounds as inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase. J Med Chem 50:2665-75 (2007) [PubMed]  Article 
Target
Name:
Enoyl-acyl-carrier protein reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
49770.86
Organism:
Plasmodium falciparum
Description:
ChEMBL_795989
Residue:
432
Sequence:
MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNKMKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRNENE
  
Inhibitor
Name:
BDBM50211911
Synonyms:
2-(3-chlorophenylthio)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)quinoline-4-carboxamide | CHEMBL227191
Type:
Small organic molecule
Emp. Form.:
C26H21ClN2OS
Mol. Mass.:
444.976
SMILES:
Clc1cccc(Sc2cc(C(=O)NC3CCCc4ccccc34)c3ccccc3n2)c1 |w:13.12|
Structure:
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