Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM50211791
Substrate
n/a
Meas. Tech.
ChEMBL_438742 (CHEMBL887899)
Ki
>10000±n/a nM
Citation
 Bruno, O; Brullo, C; Bondavalli, F; Ranise, A; Schenone, S; Falzarano, MS; Varani, K; Spisani, S 2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: new potent inhibitors of fMLP-induced neutrophil chemotaxis. Bioorg Med Chem Lett 17:3696-701 (2007) [PubMed]  Article 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM50211791
Synonyms:
(4-benzylpiperazin-1-yl)(2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)methanone | CHEMBL390200
Type:
Small organic molecule
Emp. Form.:
C23H25N5O
Mol. Mass.:
387.4775
SMILES:
O=C(N1CCN(Cc2ccccc2)CC1)c1cnn2CC(Nc12)c1ccccc1 |w:20.26|
Structure:
Search PDB for entries with ligand similarity: