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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50224582
Substrate
n/a
Meas. Tech.
ChEMBL_458318 (CHEMBL925649)
Ki
330±n/a nM
Citation
 Zhao, Z; Araldi, GL; Xiao, Y; Reddy, AP; Liao, Y; Karra, S; Brugger, N; Fischer, D; Palmer, E Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists. Bioorg Med Chem Lett 17:6572-5 (2007) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50224582
Synonyms:
4-(2-(2-(4-(3-(2-cyclopropylethyl)phenyl)-3-hydroxybutyl)-5-oxopyrazolidin-1-yl)ethyl)benzoic acid | CHEMBL249745
Type:
Small organic molecule
Emp. Form.:
C27H34N2O4
Mol. Mass.:
450.5699
SMILES:
OC(CCN1CCC(=O)N1CCc1ccc(cc1)C(O)=O)Cc1cccc(CCC2CC2)c1
Structure:
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