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Target
Mu-type opioid receptor
Ligand
BDBM50371866
Substrate
n/a
Meas. Tech.
ChEMBL_464142 (CHEMBL948304)
EC50
24900±n/a nM
Citation
 Erickson, SD; Banner, B; Berthel, S; Conde-Knape, K; Falcioni, F; Hakimi, I; Hennessy, B; Kester, RF; Kim, K; Ma, C; McComas, W; Mennona, F; Mischke, S; Orzechowski, L; Qian, Y; Salari, H; Tengi, J; Thakkar, K; Taub, R; Tilley, JW; Wang, H Potent, selective MCH-1 receptor antagonists. Bioorg Med Chem Lett 18:1402-6 (2008) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50371866
Synonyms:
CHEMBL257906
Type:
Small organic molecule
Emp. Form.:
C27H34BrN3O2
Mol. Mass.:
512.482
SMILES:
CO[C@@H]1CN(C[C@H]2Cc3ccc(Br)cc3C2)CC[C@H]1n1c(nc2cc(C)ccc12)C(C)(C)O
Structure:
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