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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50373357
Substrate
n/a
Meas. Tech.
ChEMBL_467689 (CHEMBL937611)
Kd
7.94±n/a nM
Citation
 Hall, A; Billinton, A; Brown, SH; Clayton, NM; Chowdhury, A; Giblin, GM; Goldsmith, P; Hayhow, TG; Hurst, DN; Kilford, IR; Naylor, A; Passingham, B; Winyard, L Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy. Bioorg Med Chem Lett 18:3392-9 (2008) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50373357
Synonyms:
CHEMBL256092
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O3
Mol. Mass.:
413.897
SMILES:
CC(C)OC(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCc2ccccc2)n1
Structure:
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