Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50373479
Substrate
n/a
Meas. Tech.
ChEMBL_467896 (CHEMBL925930)
IC50
3.3±n/a nM
Citation
Guo, L; Ye, Z; Ujjainwalla, F; Sings, HL; Sebhat, IK; Huber, J; Weinberg, DH; Tang, R; MacNeil, T; Tamvakopoulos, C; Peng, Q; MacIntyre, E; van der Ploeg, LH; Goulet, MT; Wyvratt, MJ; Nargund, RP Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators. Bioorg Med Chem Lett 18:3242-7 (2008) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY