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Target
Segment polarity protein dishevelled homolog DVL-1
Ligand
BDBM50373845
Substrate
n/a
Meas. Tech.
ChEMBL_468588 (CHEMBL931111)
IC50
78000±n/a nM
Citation
 Mahindroo, N; Punchihewa, C; Bail, AM; Fujii, N Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity. Bioorg Med Chem Lett 18:946-9 (2008) [PubMed]  Article 
Target
Name:
Segment polarity protein dishevelled homolog DVL-1
Synonyms:
DSH homolog 1 | DVL1 | DVL1_HUMAN | Dishevelled-1
Type:
PROTEIN
Mol. Mass.:
75195.46
Organism:
Homo sapiens (Human)
Description:
ChEMBL_468588
Residue:
695
Sequence:
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
  
Inhibitor
Name:
BDBM50373845
Synonyms:
CHEMBL402939
Type:
Small organic molecule
Emp. Form.:
C26H30N2O3
Mol. Mass.:
418.528
SMILES:
Cc1cc2n(C)c(C(=O)NC3CCCCC3)c(CCc3ccccc3)c2cc1C(O)=O
Structure:
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