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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50376238
Substrate
n/a
Meas. Tech.
ChEMBL_475725 (CHEMBL934611)
IC50
6±n/a nM
Citation
 Das, J; Moquin, RV; Pitt, S; Zhang, R; Shen, DR; McIntyre, KW; Gillooly, K; Doweyko, AM; Sack, JS; Zhang, H; Kiefer, SE; Kish, K; McKinnon, M; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors. Bioorg Med Chem Lett 18:2652-7 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50376238
Synonyms:
CHEMBL260134
Type:
Small organic molecule
Emp. Form.:
C20H16Cl2N6O
Mol. Mass.:
427.287
SMILES:
CNC(=O)c1ccc(C)c(Nc2ncnc3n(ncc23)-c2c(Cl)cccc2Cl)c1 |(3.44,3.45,;2.11,4.22,;.78,3.44,;.78,1.91,;-.56,4.21,;-.56,5.76,;-1.9,6.53,;-3.23,5.76,;-4.56,6.53,;-3.23,4.21,;-4.56,3.44,;-4.57,1.9,;-3.24,1.14,;-3.23,-.39,;-4.57,-1.17,;-5.91,-.4,;-7.37,-.87,;-8.28,.37,;-7.37,1.62,;-5.91,1.14,;-8.15,-2.2,;-9.69,-2.18,;-10.45,-.84,;-10.47,-3.5,;-9.72,-4.84,;-8.17,-4.85,;-7.4,-3.53,;-5.86,-3.54,;-1.9,3.44,)|
Structure:
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