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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50238839
Substrate
n/a
Meas. Tech.
ChEMBL_479649 (CHEMBL921450)
EC50
43±n/a nM
Citation
 Whitlock, GA; Conlon, K; McMurray, G; Roberts, LR; Stobie, A; Thurlow, RJ Novel 2-imidazoles as potent and selective alpha1A adrenoceptor partial agonists. Bioorg Med Chem Lett 18:2930-4 (2008) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM50238839
Synonyms:
CHEMBL256982 | N-(2-chloro-5-(1H-imidazol-2-yl)-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamide | N-[2-Chloro-5-(1H-imidazol-2-yl)-5,6,7,8-tetrahydro-naphthalen-1-yl]-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C14H16ClN3O2S
Mol. Mass.:
325.814
SMILES:
CS(=O)(=O)Nc1c(Cl)ccc2C(CCCc12)c1ncc[nH]1
Structure:
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