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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50261683
Substrate
n/a
Meas. Tech.
ChEMBL_532748 (CHEMBL972322)
IC50
>1000±n/a nM
Citation
 Grieco, P; Cai, M; Liu, L; Mayorov, A; Chandler, K; Trivedi, D; Lin, G; Campiglia, P; Novellino, E; Hruby, VJ Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists. J Med Chem 51:2701-7 (2008) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:
Enzyme
Mol. Mass.:
34717.23
Organism:
Homo sapiens (Human)
Description:
Q01726
Residue:
317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
  
Inhibitor
Name:
BDBM50261683
Synonyms:
(3R,6S,9S,12R,15S)-6,12-dibenzyl-9-(3-carbamimidamidopropyl)-15-(1H-imidazol-5-ylmethyl)-19-nitro-5,8,11,14,17-pentaoxo-2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17-hexadecahydro-1,4,7,10,13,16-benzothiapentazacyclononadecine-3-carboxamide | CHEMBL499491
Type:
Small organic molecule
Emp. Form.:
C40H46N12O8S
Mol. Mass.:
854.934
SMILES:
NC([NH-])=[NH+]CCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc(ccc2SC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O)[N+]([O-])=O |r,w:3.3|
Structure:
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