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Target
Meiotic mRNA stability protein kinase SSN3
Ligand
BDBM50267719
Substrate
n/a
Meas. Tech.
ChEMBL_563815 (CHEMBL994327)
IC50
>500000±n/a nM
Citation
 Gray, NS; Wodicka, L; Thunnissen, AM; Norman, TC; Kwon, S; Espinoza, FH; Morgan, DO; Barnes, G; LeClerc, S; Meijer, L; Kim, SH; Lockhart, DJ; Schultz, PG Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281:533-538 (1998) [PubMed]  Article 
Target
Name:
Meiotic mRNA stability protein kinase SSN3
Synonyms:
ARE1 | CDK8 | GIG2 | SRB10 | SSN3 | SSN3_YEAST | UME5
Type:
PROTEIN
Mol. Mass.:
62879.98
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_563815
Residue:
555
Sequence:
MYNGKDRAQNSYQPMYQRPMQVQGQQQAQSFVGKKNTIGSVHGKAPMLMANNDVFTIGPYRARKDRMRVSVLEKYEVIGYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNALRRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKKPLTVFYAIKKFKTEKDGVEQLHYTGISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRDNLATWYHSAGGRDKHALSLLYHLLNYDPIKRIDAFNALEHKYFTESDIPVSENVFEGLTYKYPARRIHTNDNDIMNLGSRTKNNTQASGITAGAAANALGGLGVNRRILAAAAAAAAAVSGNNASDEPSRKKNRR
  
Inhibitor
Name:
BDBM50267719
Synonyms:
2-(6-((3-chlorophenyl)(methyl)amino)-9-isopropyl-9H-purin-2-ylamino)ethanol | CHEMBL519036
Type:
Small organic molecule
Emp. Form.:
C17H21ClN6O
Mol. Mass.:
360.841
SMILES:
CC(C)n1cnc2c(nc(NCCO)nc12)N(C)c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: