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Target
Mu-type opioid receptor
Ligand
BDBM50294426
Substrate
n/a
Meas. Tech.
ChEMBL_575377 (CHEMBL1027051)
Ki
0.770000±n/a nM
Citation
 Nagase, H; Osa, Y; Nemoto, T; Fujii, H; Imai, M; Nakamura, T; Kanemasa, T; Kato, A; Gouda, H; Hirono, S Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett 19:2792-5 (2009) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50294426
Synonyms:
CHEMBL559518 | SN-11
Type:
Small organic molecule
Emp. Form.:
C27H28N2O
Mol. Mass.:
396.524
SMILES:
Oc1ccc2C[C@@H]3[C@@H]4Cc5cc6ccccc6nc5C[C@]4(CCN3CC3CC3)c2c1 |r,THB:24:23:7:28.4.5|
Structure:
Search PDB for entries with ligand similarity: