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Target
Nuclear receptor subfamily 4 group A member 1
Ligand
BDBM50378798
Substrate
n/a
Meas. Tech.
ChEMBL_650638 (CHEMBL1227063)
EC50
0.2780±n/a nM
Citation
 Zhan, Y; Du, X; Chen, H; Liu, J; Zhao, B; Huang, D; Li, G; Xu, Q; Zhang, M; Weimer, BC; Chen, D; Cheng, Z; Zhang, L; Li, Q; Li, S; Zheng, Z; Song, S; Huang, Y; Ye, Z; Su, W; Lin, SC; Shen, Y; Wu, Q Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol 4:548-56 (2008) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 4 group A member 1
Synonyms:
GFRP1 | HMR | NAK1 | NR4A1 | NR4A1_HUMAN | nuclear receptor subfamily 4, group A, member 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64467.13
Organism:
Homo sapiens (Human)
Description:
gi_27894344
Residue:
598
Sequence:
MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
  
Inhibitor
Name:
BDBM50378798
Synonyms:
CYTOSPORONE B
Type:
Small organic molecule
Emp. Form.:
C18H26O5
Mol. Mass.:
322.396
SMILES:
CCCCCCCC(=O)c1c(O)cc(O)cc1CC(=O)OCC
Structure:
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