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Target
Cyclin-dependent kinase 1
Ligand
BDBM5775
Substrate
n/a
Meas. Tech.
ChEMBL_660572 (CHEMBL1250280)
IC50
20±n/a nM
Citation
 Sridhar, J; Akula, N; Pattabiraman, N Selectivity and potency of cyclin-dependent kinase inhibitors. AAPS J 8:204-21 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM5775
Synonyms:
4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-pyrazolo[3,4-b]pyridine | SQ-67563 Analog 21g | pyrazolo[3,4-b]pyridine deriv.
Type:
Small organic molecule
Emp. Form.:
C17H14F3N3O2
Mol. Mass.:
349.3072
SMILES:
CCCCOc1c(cnc2[nH]ncc12)C(=O)c1c(F)cc(F)cc1F
Structure:
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