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Target
Cyclin-dependent kinase 2
Ligand
BDBM5775
Substrate
n/a
Meas. Tech.
ChEMBL_660573 (CHEMBL1250281)
IC50
50±n/a nM
Citation
 Sridhar, J; Akula, N; Pattabiraman, N Selectivity and potency of cyclin-dependent kinase inhibitors. AAPS J 8:204-21 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM5775
Synonyms:
4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-pyrazolo[3,4-b]pyridine | SQ-67563 Analog 21g | pyrazolo[3,4-b]pyridine deriv.
Type:
Small organic molecule
Emp. Form.:
C17H14F3N3O2
Mol. Mass.:
349.3072
SMILES:
CCCCOc1c(cnc2[nH]ncc12)C(=O)c1c(F)cc(F)cc1F
Structure:
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