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Target
Uridine 5'-monophosphate synthase
Ligand
BDBM50341907
Substrate
n/a
Meas. Tech.
ChEMBL_743290 (CHEMBL1767489)
Ki
759000±n/a nM
Citation
 Lewis, M; Meza-Avina, ME; Wei, L; Crandall, IE; Bello, AM; Poduch, E; Liu, Y; Paige, CJ; Kain, KC; Pai, EF; Kotra, LP Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase. J Med Chem 54:2891-901 (2011) [PubMed]  Article 
Target
Name:
Uridine 5'-monophosphate synthase
Synonyms:
Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN
Type:
Enzyme
Mol. Mass.:
52224.99
Organism:
Homo sapiens (Human)
Description:
P11172
Residue:
480
Sequence:
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
  
Inhibitor
Name:
BDBM50341907
Synonyms:
CHEMBL1765122 | ammonium 5-Cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-Monophosphate
Type:
Small organic molecule
Emp. Form.:
C10H9FN3O7P
Mol. Mass.:
333.1676
SMILES:
O[C@@H]1[C@@H](CP([O-])([O-])=O)O[C@H]([C@@H]1F)n1cc(C#N)c(=O)[nH]c1=O |r|
Structure:
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