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Target
DNA polymerase beta
Ligand
BDBM50356643
Substrate
n/a
Meas. Tech.
ChEMBL_785333 (CHEMBL1921601)
IC50
11500±n/a nM
Citation
 Maruo, S; Kuriyama, I; Kuramochi, K; Tsubaki, K; Yoshida, H; Mizushina, Y Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. Bioorg Med Chem 19:5803-12 (2011) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA Polymerase beta | DPOLB_RAT | Polb
Type:
PROTEIN
Mol. Mass.:
38334.34
Organism:
Rattus norvegicus
Description:
ChEMBL_1361926
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
  
Inhibitor
Name:
BDBM50356643
Synonyms:
CHEMBL1917198
Type:
Small organic molecule
Emp. Form.:
C28H38O4
Mol. Mass.:
438.5989
SMILES:
CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12 |c:27|
Structure:
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