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Target
Solute carrier family 12 member 5
Ligand
BDBM50384300
Substrate
n/a
Meas. Tech.
ChEMBL_818163 (CHEMBL2033940)
IC50
200±n/a nM
Citation
 Lebon, F; Pégurier, C; Ledecq, M; Mathieu, B; Bosman, N; Frycia, A; Lengelé, S; Dhurke, K; Kanduluru, AK; Meunier, S; Wagner, A; Wolff, C; Provins, L Towards a KCC2 blocker pharmacophore model. Bioorg Med Chem Lett 22:3978-82 (2012) [PubMed]  Article 
Target
Name:
Solute carrier family 12 member 5
Synonyms:
Kcc2 | S12A5_RAT | Slc12a5
Type:
PROTEIN
Mol. Mass.:
126249.28
Organism:
Rattus norvegicus
Description:
ChEMBL_818163
Residue:
1139
Sequence:
MSRRFTVTSLPPAASAASADPESRRHSVADPRRLPREDVKGDGNPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSKEHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETACDNEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSAAQKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS
  
Inhibitor
Name:
BDBM50384300
Synonyms:
CHEMBL2030661
Type:
Small organic molecule
Emp. Form.:
C25H23NO3
Mol. Mass.:
385.455
SMILES:
CC(=O)N1c2ccccc2CC1(Cc1ccccc1)C(=O)OCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: