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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50384518
Substrate
n/a
Meas. Tech.
ChEMBL_821912 (CHEMBL2039558)
IC50
1±n/a nM
Citation
 Kim, SH; Bok, JH; Lee, JH; Kim, IH; Kwon, SW; Lee, GB; Kang, SK; Park, JS; Jung, WH; Kim, HY; Rhee, SD; Ahn, SH; Bae, MA; Ha, DC; Kim, KY; Ahn, JH Synthesis and biological evaluation of cyclic sulfamide derivatives as 11ß-hydroxysteroid dehydrogenase 1 inhibitors. ACS Med Chem Lett 3:88-93 (2012) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50384518
Synonyms:
CHEMBL2036240
Type:
Small organic molecule
Emp. Form.:
C22H27Cl3N4O4S
Mol. Mass.:
549.898
SMILES:
NC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)CN1CCCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 |r,wU:9.10,wD:3.2,TLB:8:3:32:6.7.9,10:9:4.3.33:32,1:3:32:6.7.9,THB:8:7:4.3.33:32,9:7:4:33.31.32,9:31:4:6.8.7,(18.57,-16.7,;18.17,-15.21,;19.27,-14.12,;16.69,-14.8,;16.42,-16.34,;15.79,-14.71,;16.8,-13.73,;17.09,-12.31,;17.81,-13.78,;15.72,-11.64,;15.73,-10.1,;14.39,-9.33,;14.4,-7.79,;13.06,-10.09,;11.73,-9.32,;11.73,-7.77,;10.39,-6.98,;9.05,-7.77,;9.05,-9.32,;7.72,-10.09,;6.39,-9.32,;6.39,-7.78,;5.05,-10.09,;5.06,-11.64,;3.73,-12.42,;6.4,-12.4,;7.72,-11.63,;9.05,-12.39,;10.38,-10.08,;11.15,-11.42,;9.6,-11.41,;14.59,-12.65,;14.44,-14.07,;15.26,-14.13,)|
Structure:
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