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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50384520
Substrate
n/a
Meas. Tech.
ChEMBL_821912 (CHEMBL2039558)
IC50
1±n/a nM
Citation
 Kim, SH; Bok, JH; Lee, JH; Kim, IH; Kwon, SW; Lee, GB; Kang, SK; Park, JS; Jung, WH; Kim, HY; Rhee, SD; Ahn, SH; Bae, MA; Ha, DC; Kim, KY; Ahn, JH Synthesis and biological evaluation of cyclic sulfamide derivatives as 11ß-hydroxysteroid dehydrogenase 1 inhibitors. ACS Med Chem Lett 3:88-93 (2012) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50384520
Synonyms:
CHEMBL2036232
Type:
Small organic molecule
Emp. Form.:
C21H27Cl3N4O4S
Mol. Mass.:
537.887
SMILES:
CN(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)S(=O)(=O)N(C)c1c(Cl)cc(Cl)cc1Cl |r,wU:6.5,wD:13.18,TLB:5:6:14.13.12:10,16:13:10:8.7.6,15:13:10:8.7.6,6:7:14:12.11.10,THB:15:7:14.13.12:10,6:11:14:8.15.7,(12.01,-12.22,;12.01,-13.77,;13.34,-14.54,;14.67,-13.78,;14.68,-12.24,;16.01,-14.55,;16,-16.09,;17.37,-16.76,;17.08,-18.18,;16.06,-19.16,;14.72,-18.52,;14.87,-17.1,;15.54,-18.58,;16.97,-19.25,;16.7,-20.79,;18.09,-18.23,;18.45,-19.66,;18.85,-21.15,;19.55,-18.57,;10.66,-14.53,;11.43,-15.87,;9.88,-15.86,;9.33,-13.77,;9.33,-12.22,;8,-14.54,;6.67,-13.77,;6.67,-12.23,;5.33,-14.54,;5.34,-16.09,;4.01,-16.87,;6.68,-16.85,;8,-16.08,;9.33,-16.84,)|
Structure:
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