Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM50386618
Substrate
n/a
Meas. Tech.
ChEMBL_826234 (CHEMBL2049245)
Ki
300±n/a nM
Citation
 Miyakoshi, H; Miyahara, S; Yokogawa, T; Chong, KT; Taguchi, J; Endoh, K; Yano, W; Wakasa, T; Ueno, H; Takao, Y; Nomura, M; Shuto, S; Nagasawa, H; Fukuoka, M Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors. J Med Chem 55:2960-9 (2012) [PubMed]  Article 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Homo sapiens (Human)
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
  
Inhibitor
Name:
BDBM50386618
Synonyms:
CHEMBL2048443
Type:
Small organic molecule
Emp. Form.:
C17H23N2O13P3
Mol. Mass.:
556.2914
SMILES:
O[C@H]1C[C@@H](O[C@@H]1COP(O)(=O)CP(O)(=O)OP(O)(=O)OCc1ccccc1)n1ccc(=O)[nH]c1=O |r|
Structure:
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