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Target
Prostaglandin E synthase
Ligand
BDBM50386744
Substrate
n/a
Meas. Tech.
ChEMBL_826632 (CHEMBL2050886)
IC50
360±n/a nM
Citation
 Rörsch, F; Buscató, E; Deckmann, K; Schneider, G; Schubert-Zsilavecz, M; Geisslinger, G; Proschak, E; Grösch, S Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1). J Med Chem 55:3792-803 (2012) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50386744
Synonyms:
CHEMBL2046481
Type:
Small organic molecule
Emp. Form.:
C25H21Cl2N3O2
Mol. Mass.:
466.359
SMILES:
CCCc1nc2ccc(NC(=O)c3ccccc3Cl)cc2c(=O)n1Cc1cccc(Cl)c1
Structure:
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