Reaction Details
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Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM50386636
Substrate
n/a
Meas. Tech.
ChEMBL_828843 (CHEMBL2060493)
IC50
320±n/a nM
Citation
Miyahara, S; Miyakoshi, H; Yokogawa, T; Chong, KT; Taguchi, J; Muto, T; Endoh, K; Yano, W; Wakasa, T; Ueno, H; Takao, Y; Fujioka, A; Hashimoto, A; Itou, K; Yamamura, K; Nomura, M; Nagasawa, H; Shuto, S; Fukuoka, M Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors. J Med Chem 55:2970-80 (2012) [PubMed] Article More Info.:
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Homo sapiens (Human)
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
Inhibitor
Name:
BDBM50386636
Synonyms:
CHEMBL1234349
Type:
Small organic molecule
Emp. Form.:
C24H27N3O5S
Mol. Mass.:
469.553
SMILES:
OC([C@H]1CCCN1S(=O)(=O)CCCn1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1 |r|
Structure:
