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Target
Bombesin receptor subtype-3
Ligand
BDBM50381914
Substrate
n/a
Meas. Tech.
ChEMBL_857725 (CHEMBL2168752)
EC50
130±n/a nM
Citation
 Chobanian, HR; Guo, Y; Liu, P; Chioda, M; Lanza, TJ; Chang, L; Kelly, TM; Kan, Y; Palyha, O; Guan, XM; Marsh, DJ; Metzger, JM; Gorski, JN; Raustad, K; Wang, SP; Strack, AM; Miller, R; Pang, J; Madeira, M; Lyons, K; Dragovic, J; Reitman, ML; Nargund, RP; Lin, LS Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett 3:252-256 (2012) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS3_MOUSE | Brs3
Type:
PROTEIN
Mol. Mass.:
44239.49
Organism:
Mus musculus
Description:
ChEMBL_1445902
Residue:
399
Sequence:
MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
  
Inhibitor
Name:
BDBM50381914
Synonyms:
CHEMBL2023109 | MK-7725
Type:
Small organic molecule
Emp. Form.:
C25H19F6N5O5S
Mol. Mass.:
615.504
SMILES:
CC(C)(O)c1nc(no1)-c1cccc2Nc3nc(ccc3CN(c12)S(=O)(=O)c1ccc(OC(F)(F)F)cc1)C(F)(F)F
Structure:
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