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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50007407
Substrate
n/a
Meas. Tech.
ChEMBL_859806 (CHEMBL2166090)
Ki
83±n/a nM
Citation
 Lacivita, E; Patarnello, D; Stroth, N; Caroli, A; Niso, M; Contino, M; De Giorgio, P; Di Pilato, P; Colabufo, NA; Berardi, F; Perrone, R; Svenningsson, P; Hedlund, PB; Leopoldo, M Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo. J Med Chem 55:6375-80 (2012) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
49852.62
Organism:
Rattus norvegicus (rat)
Description:
Rat cloned 5-HT7R.
Residue:
448
Sequence:
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
  
Inhibitor
Name:
BDBM50007407
Synonyms:
1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen-1-yl-piperazin-1-ium | CHEMBL277120
Type:
Small organic molecule
Emp. Form.:
C14H16N2
Mol. Mass.:
212.2902
SMILES:
C1CN(CCN1)c1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: