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Target
Chloroquine resistance transporter
Ligand
BDBM50396333
Substrate
n/a
Meas. Tech.
ChEMBL_864478 (CHEMBL2176281)
IC50
10500±n/a nM
Citation
 Gemma, S; Camodeca, C; Sanna Coccone, S; Joshi, BP; Bernetti, M; Moretti, V; Brogi, S; Bonache de Marcos, MC; Savini, L; Taramelli, D; Basilico, N; Parapini, S; Rottmann, M; Brun, R; Lamponi, S; Caccia, S; Guiso, G; Summers, RL; Martin, RE; Saponara, S; Gorelli, B; Novellino, E; Campiani, G; Butini, S Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. J Med Chem 55:6948-67 (2012) [PubMed]  Article 
Target
Name:
Chloroquine resistance transporter
Synonyms:
CRT | CRT_PLAFA | PfCRT
Type:
PROTEIN
Mol. Mass.:
48687.29
Organism:
Plasmodium falciparum
Description:
ChEMBL_1364181
Residue:
424
Sequence:
MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIFIYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSKERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYHLYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKIDILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVENCGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAYYFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDSIITQ
  
Inhibitor
Name:
BDBM50396333
Synonyms:
CHEMBL2170036
Type:
Small organic molecule
Emp. Form.:
C27H26Cl2N4
Mol. Mass.:
477.428
SMILES:
Clc1cccc(c1)C(Nc1ccnc2cc(Cl)ccc12)c1ccc(CN2CCNCC2)cc1
Structure:
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