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Target
Macrophage inflammatory protein-1 alpha receptor
Ligand
BDBM50399208
Substrate
n/a
Meas. Tech.
ChEMBL_876907 (CHEMBL2184935)
IC50
>30000±n/a nM
Citation
 Cavallaro, CL; Briceno, S; Chen, J; Cvijic, ME; Davies, P; Hynes, J; Liu, RQ; Mandlekar, S; Rose, AV; Tebben, AJ; Van Kirk, K; Watson, A; Wu, H; Yang, G; Carter, PH Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis. J Med Chem 55:9643-53 (2012) [PubMed]  Article 
Target
Name:
Macrophage inflammatory protein-1 alpha receptor
Synonyms:
C-C chemokine receptor type 1
Type:
PROTEIN
Mol. Mass.:
40846.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1281523
Residue:
355
Sequence:
MEISNITETYPTTTEYDYGDSTPCQKTDVRAFGAGLLPPLYSFVFIIGVVGNILVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDNWVFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFSLRARTVTFGIITSIIIWALAILASIPALCFFKAQWEFTHHTCSPHFPDESLKTWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPNEKKAKAVRLIFAITLLFFLLWTPYNLTVFVSAFQDVLFTNQCEQSKQLDLAIQVTEVIAYTHCCVNPIIYVFVGERFRKYLRQLFQRHVAIPLAKWLPFFSVDQLERTSSLTPSTGEHELSGGF
  
Inhibitor
Name:
BDBM50399208
Synonyms:
CHEMBL2180528
Type:
Small organic molecule
Emp. Form.:
C23H27ClN2O2
Mol. Mass.:
398.926
SMILES:
CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(CC1)c1ccc(Cl)cc1 |r|
Structure:
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