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Target
Tyrosine-protein kinase SYK
Ligand
BDBM50400040
Substrate
n/a
Meas. Tech.
ChEMBL_877991 (CHEMBL2189057)
IC50
47±n/a nM
Citation
 Lucas, MC; Goldstein, DM; Hermann, JC; Kuglstatter, A; Liu, W; Luk, KC; Padilla, F; Slade, M; Villaseñor, AG; Wanner, J; Xie, W; Zhang, X; Liao, C Rational design of highly selective spleen tyrosine kinase inhibitors. J Med Chem 55:10414-23 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50400040
Synonyms:
CHEMBL2177730
Type:
Small organic molecule
Emp. Form.:
C25H24N6O5S
Mol. Mass.:
520.56
SMILES:
COc1ccc(Nc2nc(nc3scnc23)N2CCC(C2)NC(=O)c2ccc(cc2)C(O)=O)cc1OC
Structure:
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