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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50401641
Substrate
n/a
Meas. Tech.
ChEMBL_884805 (CHEMBL2216559)
EC50
5.1±n/a nM
Citation
 Shibata, Y; Kagechika, K; Yamaguchi, M; Kubo, H; Usui, H Design, synthesis and evaluation of novel zwitterionic compounds as PPARa/¿ dual agonists (1). Bioorg Med Chem Lett 22:7075-9 (2012) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50401641
Synonyms:
CHEMBL2204598
Type:
Small organic molecule
Emp. Form.:
C27H27ClN2O5
Mol. Mass.:
494.967
SMILES:
Cc1oc(nc1CN(Cc1ccco1)Cc1ccc(OC(C)(C)C(O)=O)c(Cl)c1)-c1ccccc1
Structure:
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