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Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50123591
Substrate
n/a
Meas. Tech.
ChEBML_155132
IC50
43400±n/a nM
Citation
 Ryckebusch, A; Deprez-Poulain, R; Debreu-Fontaine, MA; Vandaele, R; Mouray, E; Grellier, P; Sergheraert, C Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives. Bioorg Med Chem Lett 13:3783-7 (2003) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50123591
Synonyms:
(7-Chloro-quinolin-4-yl)-{3-[4-(3-diisobutylamino-propyl)-piperazin-1-yl]-propyl}-amine | 7-chloro-N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)quinolin-4-amine | CHEMBL124723
Type:
Small organic molecule
Emp. Form.:
C27H44ClN5
Mol. Mass.:
474.125
SMILES:
CC(C)CN(CCCN1CCN(CCCNc2ccnc3cc(Cl)ccc23)CC1)CC(C)C
Structure:
Search PDB for entries with ligand similarity: