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Target
Translocator protein
Ligand
BDBM50408747
Substrate
n/a
Meas. Tech.
ChEMBL_37807 (CHEMBL651182)
IC50
5.75±n/a nM
Citation
 Trapani, G; Franco, M; Latrofa, A; Ricciardi, L; Carotti, A; Serra, M; Sanna, E; Biggio, G; Liso, G Novel 2-phenylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity, and in vivo studies. J Med Chem 42:3934-41 (1999) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50408747
Synonyms:
CHEMBL340938
Type:
Small organic molecule
Emp. Form.:
C21H26N4O
Mol. Mass.:
350.4573
SMILES:
CCCN(CCC)C(=O)Cc1c(nc2c(N)cccn12)-c1ccccc1
Structure:
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