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Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50123561
Substrate
n/a
Meas. Tech.
ChEMBL_215891 (CHEMBL820823)
IC50
34.2±n/a nM
Citation
 Ryckebusch, A; Deprez-Poulain, R; Maes, L; Debreu-Fontaine, MA; Mouray, E; Grellier, P; Sergheraert, C Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives. J Med Chem 46:542-57 (2003) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50123561
Synonyms:
CHEMBL149751 | N-(3-(4-(3-(7-chloroquinolin-4-ylamino)propyl)piperazin-1-yl)propyl)-4-methoxybenzamide | N-(3-{4-[3-(7-Chloro-quinolin-4-ylamino)-propyl]-piperazin-1-yl}-propyl)-4-methoxy-benzamide
Type:
Small organic molecule
Emp. Form.:
C27H34ClN5O2
Mol. Mass.:
496.044
SMILES:
COc1ccc(cc1)C(=O)NCCCN1CCN(CCCNc2ccnc3cc(Cl)ccc23)CC1
Structure:
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