Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50410108
Substrate
n/a
Meas. Tech.
ChEMBL_310274 (CHEMBL833105)
EC50
0.46±n/a nM
Citation
 Li, JJ; Wang, H; Qu, F; Musial, C; Tino, JA; Robl, JA; Slusarchyk, D; Golla, R; Seethala, R; Dickinson, K; Giupponi, L; Grover, G; Sleph, P; Flynn, N; Murphy, BJ; Gordon, D; Kung, M; Stoffel, R Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues. Bioorg Med Chem Lett 15:1799-802 (2005) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50410108
Synonyms:
CHEMBL179823
Type:
Small organic molecule
Emp. Form.:
C30H43N3O5
Mol. Mass.:
525.6795
SMILES:
COc1cccc(Oc2ccc3C(N(CCc3c2)C(=O)OC(C)(C)C)C(=O)NCCN(C(C)C)C(C)C)c1
Structure:
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