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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50412228
Substrate
n/a
Meas. Tech.
ChEMBL_487568 (CHEMBL1022751)
IC50
12.59±n/a nM
Citation
 Hall, A; Billinton, A; Bristow, AK; Brown, SH; Chowdhury, A; Cutler, L; Giblin, GM; Goldsmith, P; Hayhow, TG; Kilford, IR; Naylor, A; Passingham, B; Rawlings, DA Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists. Bioorg Med Chem Lett 18:4027-32 (2008) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50412228
Synonyms:
CHEMBL479989
Type:
Small organic molecule
Emp. Form.:
C30H31ClN4O2
Mol. Mass.:
515.046
SMILES:
Cc1cc(nn1Cc1cc(Cl)ccc1OCc1ccccc1)C(=O)Nc1ccc(CN2CCCC2)cc1
Structure:
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