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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50008071
Substrate
n/a
Meas. Tech.
ChEMBL_491219 (CHEMBL992815)
Ki
6309.57±n/a nM
Citation
 Scapecchi, S; Nesi, M; Matucci, R; Bellucci, C; Buccioni, M; Dei, S; Guandalini, L; Manetti, D; Martini, E; Marucci, G; Romanelli, MN; Teodori, E; Cirilli, R Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists. J Med Chem 51:3905-12 (2008) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50008071
Synonyms:
5-methylfurmethide | CHEMBL92387 | Trimethyl-(5-methyl-furan-2-ylmethyl)-ammonium
Type:
Small organic molecule
Emp. Form.:
C9H16NO
Mol. Mass.:
154.2289
SMILES:
Cc1ccc(C[N+](C)(C)C)o1
Structure:
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