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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50412813
Substrate
n/a
Meas. Tech.
ChEMBL_494923 (CHEMBL1004666)
IC50
120.23±n/a nM
Citation
 Di Fabio, R; St-Denis, Y; Sabbatini, FM; Andreotti, D; Arban, R; Bernasconi, G; Braggio, S; Blaney, FE; Capelli, AM; Castiglioni, E; Di Modugno, E; Donati, D; Fazzolari, E; Ratti, E; Feriani, A; Contini, S; Gentile, G; Ghirlanda, D; Provera, S; Marchioro, C; Roberts, KL; Mingardi, A; Mattioli, M; Nalin, A; Pavone, F; Spada, S; Trist, DG; Worby, A Synthesis and pharmacological characterization of novel druglike corticotropin-releasing factor 1 antagonists. J Med Chem 51:7370-9 (2009) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50412813
Synonyms:
CHEMBL513937
Type:
Small organic molecule
Emp. Form.:
C22H18F3N7O2
Mol. Mass.:
469.4192
SMILES:
Cc1cc(c2CCN(c2n1)c1ccc(cc1OC(F)(F)F)C#N)-n1ccc(n1)N1CCNC1=O
Structure:
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