Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50412814
Substrate
n/a
Meas. Tech.
ChEMBL_494923 (CHEMBL1004666)
IC50
50.12±n/a nM
Citation
 Di Fabio, RSt-Denis, YSabbatini, FMAndreotti, DArban, RBernasconi, GBraggio, SBlaney, FECapelli, AMCastiglioni, EDi Modugno, EDonati, DFazzolari, ERatti, EFeriani, AContini, SGentile, GGhirlanda, DProvera, SMarchioro, CRoberts, KLMingardi, AMattioli, MNalin, APavone, FSpada, STrist, DGWorby, A Synthesis and pharmacological characterization of novel druglike corticotropin-releasing factor 1 antagonists. J Med Chem 51:7370-9 (2009) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50412814
Synonyms:
CHEMBL456660
Type:
Small organic molecule
Emp. Form.:
C23H23N7O
Mol. Mass.:
413.475
SMILES:
CCc1cc(ccc1N1CCc2c1nc(C)cc2-n1ccc(n1)N1CCNC1=O)C#N
Structure:
Search PDB for entries with ligand similarity: