Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50413478
Substrate
n/a
Meas. Tech.
ChEMBL_567123 (CHEMBL1030802)
Ki
3.72±n/a nM
Citation
 Akgün, E; Körner, M; Gao, F; Harikumar, KG; Waser, B; Reubi, JC; Portoghese, PS; Miller, LJ Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors. J Med Chem 52:2138-47 (2009) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
47859.34
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-1 receptors in HEK 293 cells.
Residue:
428
Sequence:
MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ
  
Inhibitor
Name:
BDBM50413478
Synonyms:
CHEMBL515288
Type:
Small organic molecule
Emp. Form.:
C23H19IN4O2
Mol. Mass.:
510.327
SMILES:
CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(I)c2)C1=O)c1ccccc1 |r,c:9|
Structure:
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