Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50414798
Substrate
n/a
Meas. Tech.
ChEMBL_587793 (CHEMBL1042247)
Ki
0.724±n/a nM
Citation
 Dvorak, CA; Apodaca, R; Xiao, W; Jablonowski, JA; Bonaventure, P; Dugovic, C; Shelton, J; Lord, B; Miller, K; Dvorak, LK; Lovenberg, TW; Carruthers, NI Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines. Eur J Med Chem 44:4098-106 (2009) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50414798
Synonyms:
CHEMBL575172
Type:
Small organic molecule
Emp. Form.:
C21H31N3
Mol. Mass.:
325.4909
SMILES:
CN1CCN(Cc2cccc(c2)C#CCCN2CCCCC2)CC1
Structure:
Search PDB for entries with ligand similarity: