Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 6
Ligand
BDBM10880
Substrate
n/a
Meas. Tech.
ChEMBL_838527 (CHEMBL2078155)
Ki
1100000±n/a nM
Citation
 Uwai, Y; Saito, H; Hashimoto, Y; Inui, KI Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther 295:261-5 (2000) [PubMed] 
Target
Name:
Solute carrier family 22 member 6
Synonyms:
Oat1 | Organic anion transporter 1 | S22A6_RAT | Slc22a6 | rOAT1 | rROAT1 | renal organic anion transporter 1
Type:
PROTEIN
Mol. Mass.:
60784.17
Organism:
Rattus norvegicus
Description:
ChEMBL_838479
Residue:
551
Sequence:
MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEAWLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKELTLSKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKSRSRGKQNQQQQEQQKQMMPLQASTQEKNGL
  
Inhibitor
Name:
BDBM10880
Synonyms:
AZA | AZA2 | AZM acetazolamide | Acerazolamide, AAZ | Acetazolamide | Acetazolamide (AAZ) | Acetazolamide (AZA) | Acetazolamide (AZM) | Acetazolamide, 5 | Acetazolamide, AAZ | Acetazolamide, AZA | Acetazolamide, AZM | CHEMBL20 | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Sulfonamide, 1 | US10172837, Acetazolamide | US11278534, Example acetazolamide | US11535599, Example acetazolamide | sulfonamide 1
Type:
Small organic molecule
Emp. Form.:
C4H6N4O3S2
Mol. Mass.:
222.245
SMILES:
CC(=O)Nc1nnc(s1)S(N)(=O)=O
Structure:
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