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Target
Solute carrier organic anion transporter family member 1A4
Ligand
BDBM46355
Substrate
n/a
Meas. Tech.
ChEMBL_836631 (CHEMBL2077473)
Ki
37±n/a nM
Citation
 Sugiyama, D; Kusuhara, H; Shitara, Y; Abe, T; Meier, PJ; Sekine, T; Endou, H; Suzuki, H; Sugiyama, Y Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther 298:316-22 (2001) [PubMed] 
Target
Name:
Solute carrier organic anion transporter family member 1A4
Synonyms:
Brain digoxin carrier protein | Brain-specific organic anion transporter | OATP-B1 | Oatp1a4 | Oatp2 | SO1A4_RAT | Slc21a5 | Slco1a4 | Sodium-independent organic anion-transporting polypeptide 2 | Solute carrier family 21 member 5
Type:
PROTEIN
Mol. Mass.:
73261.82
Organism:
Rattus norvegicus
Description:
ChEMBL_836631
Residue:
661
Sequence:
MGKSEKRVATHGVRCFAKIKMFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSIVGLINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFLISLPHFLMGQYEYETILPTSNVSSNSFFCVENRSQTLNPTQDPSECVKEMKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILETGMTIGPLIGLLLASSCANIYVDIESVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSFPFFFFPKTLPKEGLQENVDGTENAKEKKHRKKAKEEKRGITKDFFVFMKSLSCNPIYMLFILISVLQFNAFINSFTFMPKYLEQQYGKSTAEVVFLMGLYMLPPICLGYLIGGLIMKKFKVTVKKAAHLAFWLCLSEYLLSFLSYVMTCDNFPVAGLTTSYEGVQHQLYVENKVLADCNTRCNCSTNTWDPVCGDNGLAYMSACLAGCEKSVGTGTNMVFQNCSCIQSSGNSSAVLGLCNKGPDCANKLQYFLIIAIFGCFIYSLAGIPGYMVLLRCIKSEEKSLGVGLHAFCIRILAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRLYLGLPAALRGASFVPAFFILRLTRTFQFPGDIESSKTDHAEMKLTLKESECTEVLRSKVTED
  
Inhibitor
Name:
BDBM46355
Synonyms:
DIGOXIN | MLS000069819 | SMR000059217 | US10668094, Compound Digoxin | cid_2724385
Type:
Small organic molecule
Emp. Form.:
C41H64O14
Mol. Mass.:
780.9385
SMILES:
C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]1[C@@H](O)C[C@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3CC[C@@]4(C)[C@H](CC[C@@H]5[C@@H]4C[C@@H](O)[C@]4(C)[C@H](CC[C@]54O)C4=CC(=O)OC4)C3)O[C@@H]2C)O[C@@H]1C |t:46|
Structure:
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