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Target
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
Ligand
BDBM50420306
Substrate
n/a
Meas. Tech.
ChEMBL_839771 (CHEMBL2089693)
IC50
7200±n/a nM
Citation
 Cho, YS; Angove, H; Brain, C; Chen, CH; Cheng, H; Cheng, R; Chopra, R; Chung, K; Congreve, M; Dagostin, C; Davis, DJ; Feltell, R; Giraldes, J; Hiscock, SD; Kim, S; Kovats, S; Lagu, B; Lewry, K; Loo, A; Lu, Y; Luzzio, M; Maniara, W; McMenamin, R; Mortenson, PN; Benning, R; Rees, DC; Shen, J; Smith, T; Wang, Y; Williams, G; Woolford, AJ; Wrona, W; Xu, M; Yang, F; Howard, S Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors. ACS Med Chem Lett 3:445-449 (2012) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
Synonyms:
CDK6/CycD3 | CDK6/D3 | CDK6/G1/S-specific cyclin D3 | CDK6/cyclin D3 | Cyclin-dependent kinase 6 | Cyclin-dependent kinase 6/G1/S-specific cyclin D3
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Component 2
Name:
G1/S-specific cyclin-D3
Synonyms:
CCND3 | CCND3_HUMAN
Type:
Enzyme
Mol. Mass.:
32521.90
Organism:
Homo sapiens (Human)
Description:
P30281
Residue:
292
Sequence:
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
  
Inhibitor
Name:
BDBM50420306
Synonyms:
CHEMBL2089060
Type:
Small organic molecule
Emp. Form.:
C12H9N3O
Mol. Mass.:
211.2194
SMILES:
O=C(c1ccc[nH]1)c1nc2ccccc2[nH]1
Structure:
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