Reaction Details Report a problem with these data
Target
Alpha-1B adrenergic receptor
Ligand
BDBM50219256
Substrate
n/a
Meas. Tech.
ChEMBL_34480 (CHEMBL875931)
EC50
<100000±n/a nM
Citation
 Navas, F; Bishop, MJ; Garrison, DT; Hodson, SJ; Speake, JD; Bigham, EC; Drewry, DH; Saussy, DL; Liacos, JH; Irving, PE; Gobel, MJ 2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series. Bioorg Med Chem Lett 12:575-9 (2002) [PubMed]  Article 
Target
Name:
Alpha-1B adrenergic receptor
Synonyms:
ADA1B_HUMAN | ADRA1B | Adrenergic alpha1B | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha-1B adrenergic receptor
Type:
Enzyme
Mol. Mass.:
56862.13
Organism:
Homo sapiens (Human)
Description:
P35368
Residue:
520
Sequence:
MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
  
Inhibitor
Name:
BDBM50219256
Synonyms:
CHEMBL350906
Type:
Small organic molecule
Emp. Form.:
C16H15F3N4
Mol. Mass.:
320.3123
SMILES:
FC(F)(F)c1cccnc1-c1ccccc1NCC1=NCCN1 |t:20|
Structure:
Search PDB for entries with ligand similarity: