Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50422636
Substrate
n/a
Meas. Tech.
ChEMBL_313631 (CHEMBL835775)
IC50
21878±n/a nM
Citation
 Breschi, MC; Calderone, V; Digiacomo, M; Martelli, A; Martinotti, E; Minutolo, F; Rapposelli, S; Balsamo, A NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs. J Med Chem 47:5597-600 (2004) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50422636
Synonyms:
3-Nitrooxymethyl-Benzoic Acid | CHEMBL362550
Type:
Small organic molecule
Emp. Form.:
C8H7NO5
Mol. Mass.:
197.1449
SMILES:
OC(=O)c1cccc(CO[N+]([O-])=O)c1
Structure:
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