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Found 537 with Last Name = 'calderone' and Initial = 'v'
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.240nMpH: 6.8Assay Description:Inhibition of human MMP12 catalytic domain (98 to 266) at pH 6.8 by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50426080(CHEMBL2316257)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332946(CHEMBL1234724 | N-hydroxy-2-(N-(2-hydroxyethyl)-4-...)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434226(CHEMBL2385483)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332948((R)-2-(N-((S)-2,3-dihydroxypropyl)-4-methoxyphenyl...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332945(CHEMBL1232074 | N-hydroxy-2-(4-methoxy-N-(2-((2R,3...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434222(CHEMBL2385487)
Affinity DataKi:  2nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50294120(2-(biphenyl-4-ylsulfonamido)-N-hydroxyacetamide | ...)
Affinity DataKi:  2nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332949((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332952(CHEMBL1233772 | N-hydroxy-2-(N-(2-hydroxyethyl)bip...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332950((2R,3R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamid...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332947((S)-2-(N-(2,3-dihydroxypropyl)-4-methoxyphenylsulf...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332952(CHEMBL1233772 | N-hydroxy-2-(N-(2-hydroxyethyl)bip...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434224(CHEMBL2385485)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434213(CHEMBL2385489)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332949((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Affinity DataKi:  6nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434221(CHEMBL2385490)
Affinity DataKi:  6nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332948((R)-2-(N-((S)-2,3-dihydroxypropyl)-4-methoxyphenyl...)
Affinity DataKi:  7nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434223(CHEMBL2385486)
Affinity DataKi:  7nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332946(CHEMBL1234724 | N-hydroxy-2-(N-(2-hydroxyethyl)-4-...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332948((R)-2-(N-((S)-2,3-dihydroxypropyl)-4-methoxyphenyl...)
Affinity DataKi:  8nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332947((S)-2-(N-(2,3-dihydroxypropyl)-4-methoxyphenylsulf...)
Affinity DataKi:  8nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332949((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Affinity DataKi:  9nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434219(CHEMBL2385492)
Affinity DataKi:  9nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Affinity DataKi:  9nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332945(CHEMBL1232074 | N-hydroxy-2-(4-methoxy-N-(2-((2R,3...)
Affinity DataKi:  9.10nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332950((2R,3R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamid...)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434225(CHEMBL2385484)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434227(CHEMBL2385482)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332950((2R,3R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamid...)
Affinity DataKi:  11nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332946(CHEMBL1234724 | N-hydroxy-2-(N-(2-hydroxyethyl)-4-...)
Affinity DataKi:  13nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332945(CHEMBL1232074 | N-hydroxy-2-(4-methoxy-N-(2-((2R,3...)
Affinity DataKi:  14.3nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50426079(CHEMBL2316258)
Affinity DataKi:  15nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50206936(CHEMBL375367 | N-isopropyl-2-(5-nitro-1H-indol-3-y...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]flumazenil from rat GABAA alpha1beta2gamma2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434214(CHEMBL2385488)
Affinity DataKi:  15nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434215(CHEMBL2385481)
Affinity DataKi:  16nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50426081(CHEMBL2316256)
Affinity DataKi:  16nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50206941(CHEMBL376508 | N-(4-bromobenzyl)-2-(1H-indol-3-yl)...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]flumazenil from rat GABAA alpha1beta2gamma2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332953((S)-2-(N-(2,3-dihydroxypropyl)biphenyl-4-ylsulfona...)
Affinity DataKi:  18nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
Affinity DataKi:  20nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434216(CHEMBL2385480)
Affinity DataKi:  23nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332947((S)-2-(N-(2,3-dihydroxypropyl)-4-methoxyphenylsulf...)
Affinity DataKi:  24nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  25nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332952(CHEMBL1233772 | N-hydroxy-2-(N-(2-hydroxyethyl)bip...)
Affinity DataKi:  31nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50206939(CHEMBL223707 | N-(p-methylbenzyl)-5-nitroindol-3-y...)
Affinity DataKi:  31.3nMAssay Description:Displacement of [3H]flumazenil from rat GABAA alpha1beta2gamma2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332948((R)-2-(N-((S)-2,3-dihydroxypropyl)-4-methoxyphenyl...)
Affinity DataKi:  32nMAssay Description:Inhibition of MMP1 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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