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Target
Type-1 angiotensin II receptor
Ligand
BDBM50422637
Substrate
n/a
Meas. Tech.
ChEMBL_313631 (CHEMBL835775)
IC50
2818±n/a nM
Citation
 Breschi, MC; Calderone, V; Digiacomo, M; Martelli, A; Martinotti, E; Minutolo, F; Rapposelli, S; Balsamo, A NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs. J Med Chem 47:5597-600 (2004) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50422637
Synonyms:
CHEMBL186572 | Losartan 3-[(Nitrooxy)Methyl]Benzoate
Type:
Small organic molecule
Emp. Form.:
C30H28ClN7O5
Mol. Mass.:
602.04
SMILES:
CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+]([O-])=O)c2)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure:
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