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Target
Intermediate conductance calcium-activated potassium channel protein 4
Ligand
BDBM50425107
Substrate
n/a
Meas. Tech.
ChEMBL_936631 (CHEMBL2319030)
IC50
7700±n/a nM
Citation
 Olsson, RI; Jacobson, I; Boström, J; Fex, T; Björe, A; Olsson, C; Sundell, J; Gran, U; Öhrn, A; Nordin, A; Gyll, J; Thorstensson, M; Hayen, A; Aplander, K; Hidestål, O; Jiang, F; Linhardt, G; Forsström, E; Collins, T; Sundqvist, M; Lindhardt, E; Åstrand, A; Löfberg, B Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5. Bioorg Med Chem Lett 23:706-10 (2013) [PubMed]  Article 
Target
Name:
Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:
IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:
PROTEIN
Mol. Mass.:
47723.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361891
Residue:
427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
  
Inhibitor
Name:
BDBM50425107
Synonyms:
CHEMBL2312930
Type:
Small organic molecule
Emp. Form.:
C25H20N3OP
Mol. Mass.:
409.4196
SMILES:
O=P(NCc1cccnc1-c1cccc(c1)C#N)(c1ccccc1)c1ccccc1
Structure:
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