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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50425098
Substrate
n/a
Meas. Tech.
ChEMBL_936633 (CHEMBL2319032)
IC50
1300±n/a nM
Citation
 Olsson, RI; Jacobson, I; Boström, J; Fex, T; Björe, A; Olsson, C; Sundell, J; Gran, U; Öhrn, A; Nordin, A; Gyll, J; Thorstensson, M; Hayen, A; Aplander, K; Hidestål, O; Jiang, F; Linhardt, G; Forsström, E; Collins, T; Sundqvist, M; Lindhardt, E; Åstrand, A; Löfberg, B Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5. Bioorg Med Chem Lett 23:706-10 (2013) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50425098
Synonyms:
CHEMBL2313229
Type:
Small organic molecule
Emp. Form.:
C24H22N3OP
Mol. Mass.:
399.4247
SMILES:
O=P(N(Cc1ccccn1)Cc1ccccn1)(c1ccccc1)c1ccccc1
Structure:
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