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Target
Proteasome subunit beta type-5
Ligand
BDBM50427003
Substrate
n/a
Meas. Tech.
ChEMBL_939307 (CHEMBL2327272)
IC50
630±n/a nM
Citation
 Geurink, PP; van der Linden, WA; Mirabella, AC; Gallastegui, N; de Bruin, G; Blom, AE; Voges, MJ; Mock, ED; Florea, BI; van der Marel, GA; Driessen, C; van der Stelt, M; Groll, M; Overkleeft, HS; Kisselev, AF Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites. J Med Chem 56:1262-75 (2013) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50427003
Synonyms:
CHEMBL2326262
Type:
Small organic molecule
Emp. Form.:
C36H46N8O5S
Mol. Mass.:
702.866
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(N)cc1)\C=C\S(C)(=O)=O |r|
Structure:
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